MS-8209, a new amphotericin B derivative, provides enhanced efficacy in delaying hamster scrapie - EnvA - École nationale vétérinaire d'Alfort
Article Dans Une Revue Antimicrobial Agents and Chemotherapy Année : 1995

MS-8209, a new amphotericin B derivative, provides enhanced efficacy in delaying hamster scrapie

R Demaimay
  • Fonction : Auteur
C Lasmezas
  • Fonction : Auteur
J Deslys
  • Fonction : Auteur
M Seman
  • Fonction : Auteur
D Dormont
  • Fonction : Auteur

Résumé

To test the efficacy of a new amphotericin B derivative, MS-8209, in delaying scrapie, hamsters were infected intracerebrally with the 263K scrapie agent and treated with MS-8209 either early in the course of the disease or continuously. The results show that (i) all treatments lengthened the incubation period of hamster scrapie, (ii) continuous treatment with MS-8209 doubled the length of the incubation period compared with that observed in infected, untreated animals, and (iii) all treatments delayed the accumulation of a proteinase-resistant prion protein and glial fibrillary acidic protein in the brain. These findings suggest that MS-8209 is a powerful tool for investigating the pathogenesis of transmissible subacute spongiform encephalopathies.

Dates et versions

hal-04525488 , version 1 (28-03-2024)

Licence

Copyright (Tous droits réservés)

Identifiants

Citer

K Adjou, R Demaimay, C Lasmezas, J Deslys, M Seman, et al.. MS-8209, a new amphotericin B derivative, provides enhanced efficacy in delaying hamster scrapie. Antimicrobial Agents and Chemotherapy, 1995, 39 (12), pp.2810-2812. ⟨10.1128/AAC.39.12.2810⟩. ⟨hal-04525488⟩

Collections

CEA ENVA
8 Consultations
0 Téléchargements

Altmetric

Partager

More