Azole Resistance in Clinical and Environmental Aspergillus Isolates from the French West Indies (Martinique) - EnvA - École nationale vétérinaire d'Alfort Accéder directement au contenu
Article Dans Une Revue Journal of Fungi Année : 2021

Azole Resistance in Clinical and Environmental Aspergillus Isolates from the French West Indies (Martinique)

Résumé

The emergence of azole resistant Aspergillus spp., especially Aspergillus fumigatus, has been described in several countries around the world with varying prevalence depending on the country. To our knowledge, azole resistance in Aspergillus spp. has not been reported in the West Indies yet. In this study, we investigated the antifungal susceptibility of clinical and environmental isolates of Aspergillus spp. from Martinique, and the potential resistance mechanisms associated with mutations in cyp51A gene. Overall, 208 Aspergillus isolates were recovered from clinical samples (n = 45) and environmental soil samples (n = 163). They were screened for resistance to azole drugs using selective culture media. The Minimum Inhibitory Concentrations (MIC) towards voriconazole, itraconazole, posaconazole and isavuconazole, as shown by the resistant isolates, were determined using the European Committee on Antimicrobial Susceptibility Testing (EUCAST) microdilution broth method. Eight isolates (A. fumigatus, n = 6 and A. terreus, n = 2) had high MIC for at least one azole drug. The sequencing of cyp51A gene revealed the mutations G54R and TR34/L98H in two A. fumigatus clinical isolates. Our study showed for the first time the presence of azole resistance in A. fumigatus and A. terreus isolates in the French West Indies.
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Dates et versions

hal-04313108 , version 1 (07-01-2024)

Identifiants

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Lorra Monpierre, Nicole Desbois-Nogard, Isabel Valsecchi, Marielle Bajal, Cécile Angebault, et al.. Azole Resistance in Clinical and Environmental Aspergillus Isolates from the French West Indies (Martinique). Journal of Fungi, 2021, 7 (5), pp.355. ⟨10.3390/jof7050355⟩. ⟨hal-04313108⟩
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