Effects of MS-8209, an Amphotericin B Derivative, on Tumor Necrosis Factor Alpha Synthesis and Human Immunodeficiency Virus Replication in Macrophages - EnvA - École nationale vétérinaire d'Alfort
Article Dans Une Revue Antimicrobial Agents and Chemotherapy Année : 2000

Effects of MS-8209, an Amphotericin B Derivative, on Tumor Necrosis Factor Alpha Synthesis and Human Immunodeficiency Virus Replication in Macrophages

Pascal Clayette
  • Fonction : Auteur
Marc Martin
  • Fonction : Auteur
Vincent Beringue
  • Fonction : Auteur
Nathalie Dereuddre-Bosquet
  • Fonction : Auteur
Michel Seman
  • Fonction : Auteur
Dominique Dormont
  • Fonction : Auteur

Résumé

ABSTRACT Amphotericin B derivatives, such as MS-8209, have been evaluated as a therapeutic approach to human immunodeficiency virus (HIV) infection. We show that MS-8209, like amphotericin B, increases tumor necrosis factor alpha (TNF-α) mRNA expression and TNF-α production and consequently HIV replication in human macrophages. These effects confirm the pharmacological risk associated with the administration of amphotericin B or its derivatives to HIV-infected patients.

Dates et versions

hal-04525444 , version 1 (28-03-2024)

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Citer

Pascal Clayette, Marc Martin, Vincent Beringue, Nathalie Dereuddre-Bosquet, Karim Adjou, et al.. Effects of MS-8209, an Amphotericin B Derivative, on Tumor Necrosis Factor Alpha Synthesis and Human Immunodeficiency Virus Replication in Macrophages. Antimicrobial Agents and Chemotherapy, 2000, 44 (2), pp.405-407. ⟨10.1128/AAC.44.2.405-407.2000⟩. ⟨hal-04525444⟩
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